Article

The Site Frequency Spectrum under Finite and Time-Varying Mutation Rates

2018-07-24

Abstract excerpt

The diversity in genomes is due to the accumulation of mutations and the site frequency spectrum (SFS) is a popular statistic for summarizing genomic data. The current coalescent algorithm for calculating the SFS for a given demography assumes the μ → 0 limit, where μ is the mutation probability (or rate) per base pair per generation. The algorithm is applicable when μN , N being the haploid population size, i...

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Literature Corpus work: 8011556a-5d21-57c5-a667-e0c4d9ea6c68
DOI: 10.1101/375907

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