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Article

The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast.

PLoS genetics - 1 Jul 2017

Patchett Stephanie, Musalgaonkar Sharmishtha, Malyutin Andrey G, Johnson Arlen W

Abstract excerpt

Mutations in the ribosomal protein Rpl10 (uL16) can be drivers of T-cell acute lymphoblastic leukemia (T-ALL). We previously showed that these T-ALL mutations disrupt late cytoplasmic maturation of the 60S ribosomal subunit, blocking the release of the trans-acting factors Nmd3 and Tif6 in S. cerevisiae. Consequently, these mutant ribosomes do not efficiently pass the cytoplasmic quality control checkpoint and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28715419
DOI: 10.1371/journal.pgen.1006894
PMCID: PMC5536393

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The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast.PMID 28715419Read ↗

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.Semantic proximity Read ↗

Mapping the functional domains of yeast NMD3, the nuclear export adapter for the 60 S ribosomal subunit.Semantic proximity Read ↗

Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits.Semantic proximity Read ↗

Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p.Semantic proximity Read ↗

The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.Semantic proximity Read ↗

Integrity of the P-site is probed during maturation of the 60S ribosomal subunit.Semantic proximity Read ↗

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.Semantic proximity Read ↗

Mutational analysis of the ribosomal protein Rpl10 from yeast.Semantic proximity Read ↗

Yvh1 is required for a late maturation step in the 60S biogenesis pathway.Semantic proximity Read ↗

Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit.Semantic proximity Read ↗

Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3.Semantic proximity Read ↗

Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates.Semantic proximity Read ↗

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