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Article

TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.

Cell research - 1 Jan 2010

Sondarva Gautam, Kundu Chanakya N, Mehrotra Suneet, Mishra Rajakishore, Rangasamy Velusamy, Sathyanarayana Pradeep, Ray Rajarshi S, Rana Basabi, Rana Ajay

Abstract excerpt

Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase that is activated by tumor necrosis factor-alpha (TNF-alpha) and specifically activates c-Jun N-terminal kinase (JNK) on TNF-alpha stimulation. The mechanism by which TNF-alpha activates MLK3 is still not known. TNF...

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Source

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Identifiers

PMID: 19918265
DOI: 10.1038/cr.2009.125
PMCID: PMC2801772

Genes

TNF
TRAF2
TRAF5
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19918265-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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