Article
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation.
Molecular and cellular biology - 1 Jan 2002
Rabinovich Efrat, Kerem Anat, Fröhlich Kai-Uwe, Diamant Noam, Bar-Nun Shoshana
Abstract excerpt
Endoplasmic reticulum-associated degradation (ERAD) disposes of aberrant proteins in the secretory pathway. Protein substrates of ERAD are dislocated via the Sec61p translocon from the endoplasmic reticulum to the cytosol, where they are ubiquitinated and degraded by the proteasome. Since the Sec61p channel is also responsible for import of nascent proteins, this bidirectional passage should be coordinated,...
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