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Article

A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.

The Journal of biological chemistry - 14 Mar 2008

Lipson Carni, Alalouf Guy, Bajorek Monika, Rabinovich Efrat, Atir-Lande Avigail, Glickman Michael, Bar-Nun Shoshana

Abstract excerpt

Endoplasmic reticulum (ER)-associated degradation (ERAD) eliminates aberrant proteins from the ER by dislocating them to the cytoplasm where they are tagged by ubiquitin and degraded by the proteasome. Six distinct AAA-ATPases (Rpt1-6) at the base of the 19S regulatory particle of the 26S proteasome recognize, unfold, and translocate substrates into the 20S catalytic chamber. Here we show unique contributions of...

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PMID: 18174173
DOI: 10.1074/jbc.M705893200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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