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Article

Molecular docking of competitive phosphodiesterase inhibitors.

Molecular pharmacology - 1 Jan 2002

Dym Orly, Xenarios Ioannis, Ke Hengming, Colicelli John

Abstract excerpt

Mammalian phosphodiesterases types 3 and 4 (PDE3 and PDE4) hydrolyze cAMP and are essential for the regulation of this intracellular second messenger. These enzymes share structural and biochemical similarities, but each can be distinguished by its sensitivity to isoenzyme-specific, substrate-competitive inhibitors. We present a model configuration for the PDE4 substrate (cAMP) and a PDE4-specific inhibitor...

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Source

Identifiers

PMID: 11752202
DOI: 10.1124/mol.61.1.20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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