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Article

Structural insight into substrate specificity of phosphodiesterase 10.

Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2007

Wang Huanchen, Liu Yudong, Hou Jing, Zheng Meiyan, Robinson Howard, Ke Hengming

Abstract excerpt

Phosphodiesterases (PDEs) hydrolyze the second messengers cAMP and cGMP. It remains unknown how individual PDE families selectively recognize cAMP and cGMP. This work reports structural studies on substrate specificity. The crystal structures of the catalytic domains of the D674A and D564N mutants of PDE10A2 in complex with cAMP and cGMP reveal that two substrates bind to the active site with the same syn...

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Identifiers

PMID: 17389385
DOI: 10.1073/pnas.0700279104
PMCID: PMC1851569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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