Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes.

doi:10.4049/jimmunol.168.1.44

Article

Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2002

Ravasi Timothy, Wells Christine, Forest Alistair, Underhill David M, Wainwright Brandon J, Aderem Alan, Grimmond Sean, Hume David A

Abstract excerpt

Microbial products such as LPS stimulate macrophages to produce a wide diversity of inducible gene products needed for immediate host defense and priming of an appropriate acquired immune response. In this study, we have examined LPS-inducible gene expression in subclones of a mouse macrophage cell line, RAW264, using cDNA microarrays. Even archetypal target genes such as TNF-alpha were not induced in all...

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