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Article

Macrophage heterogeneity occurs through a developmental mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1991

Witsell A L, Schook L B

Abstract excerpt

The versatility and importance of macrophages in host defense and homeostasis have long been recognized. Anatomically, macrophages isolated from various tissues manifest extreme differences in shape, in metabolic and functional activities, and in the expression of macrophage-specific markers. To determine the mechanisms responsible for generating macrophage heterogeneity, we have employed the reverse...

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Identifiers

PMID: 1705715
DOI: 10.1073/pnas.88.5.1963
PMCID: PMC51146

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