Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein.

The Journal of biological chemistry - 5 Feb 2010

Behrendt Marc, Polaina Julio, Naim Hassan Y

Abstract excerpt

Human intestinal lactase-phlorizin hydrolase, LPH, encompasses four homologous domains, which presumably have evolved from two subsequent duplications of one ancestral gene. The profragment, LPHalpha, comprises homologous domains I and II and functions as an intramolecular chaperone in the contex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Golgi Apparatus
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Mucosa

Share to Lactose

Share to Luminescent Proteins

Share to Microscopy, Confocal

Share to Protein Multimerization

Source

Open in PubMed Open full text

Identifiers

PMID: 19955176
DOI: 10.1074/jbc.M109.060780
PMCID: PMC2823554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19955176-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein.PMID 19955176Read ↗

The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.Semantic proximity Read ↗

Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency.Semantic proximity Read ↗

The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.Semantic proximity Read ↗

Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene.Semantic proximity Read ↗

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.Semantic proximity Read ↗

Genetic analysis reveals a robust and hierarchical recruitment of the LolA chaperone to the LolCDE lipoprotein transporterSemantic proximity Read ↗

RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi.Semantic proximity Read ↗

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteinsSemantic proximity Read ↗

Endoplasmic reticulum-retained podocin mutants are massively degraded by the proteasome.Semantic proximity Read ↗

Topologically conserved residues direct heme transport in HRG-1-related proteins.Semantic proximity Read ↗

Conserved extracellular cysteine residues and cytoplasmic loop-loop interplay are required for functionality of the heptahelical MLO protein.Semantic proximity Read ↗

Importance of two PDZ domains for the proteolytic and chaperone activities of Helicobacter pylori serine protease HtrA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.