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Article

Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity.

The Journal of biological chemistry - 8 Mar 2002

Arai Kuniaki, Masutomi Kenkichi, Khurts Shilagardy, Kaneko Shuichi, Kobayashi Kenichi, Murakami Seishi

Abstract excerpt

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, contains motifs conserved among reverse transcriptases. Several nucleic acid-dependent polymerases that share a "fingers, palm, and thumb substructure" were shown to oligomerize. Here we demonstrate that hTERT also has this ability using partially purified recombinant hTERTs and mammalian cells co-expressing differently tagged...

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Identifiers

PMID: 11751869
DOI: 10.1074/jbc.M111068200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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