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Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO2 and carbon black

25 Apr 2025

Abstract excerpt

BACKGROUND: Chronic inhalation of titanium dioxide or carbon black can lead, at high exposure, to lung overload, and can induce chronic inflammation and lung cancer in rats. Whether this rat adverse response is predictive for humans has been questioned for more than 40 years. Currently, these particles are conservatively considered as possible human carcinogens. OBJECTIVE: To clarify the mechanisms of the adverse...

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PMID: 40281615
DOI: 10.1186/s12989-025-00624-x

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