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The Contact Allergen Nickel Triggers a Unique Inflammatory and Proangiogenic Gene Expression Pattern via Activation of NF-κB and Hypoxia-Inducible Factor-1α

1 Mar 2007

Abstract excerpt

Nickel compounds are prime inducers of contact allergy reactions in humans. To identify the signal transduction pathways mediating the cellular responses to nickel and to elucidate their hierarchy, we performed Affymetrix gene profiling using human primary endothelial cells, which strongly respond to nickel stimulation. Overall, we found 258 significantly modulated transcripts, comprising 140 up-regulated and 118...

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Share to Contact Dermatitis and Allergies
Share to Heme Oxygenase-1 and Carbon Monoxide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17312168
DOI: 10.4049/jimmunol.178.5.3198

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