Article
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome.
American journal of respiratory and critical care medicine - 15 Dec 2001
Sullivan K J, Kissoon N, Duckworth L J, Sandler E, Freeman B, Bayne E, Sylvester J E, Lima J J
Abstract excerpt
Abnormalities of nitric oxide metabolism have been implicated in the pathogenesis of acute chest syndrome in subjects with sickle cell anemia. It is not known whether exhaled nitric oxide levels (FE(NO)) are abnormal in children with a history of the acute chest syndrome (ACS). We compared FE(NO), plasma nitric oxide metabolites (NO(x)), serum arginine and citrulline levels, and the number of AAT repeats in...
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