Article
Profiling nitric oxide metabolites in patients with idiopathic pulmonary arterial hypertension.
The European respiratory journal - 1 Nov 2016
Zhang Rui, Wang Xiao-Jian, Zhang Hong-Da, Sun Xiao-Qing, Zhao Qin-Hua, Wang Lan, He Jing, Jiang Xin, Liu Jin-Ming, Jing Zhi-Cheng
Abstract excerpt
Intact nitric oxide (NO) signalling is critical to maintaining appropriate pulmonary vascular tone. NO bioavailability is reduced in patients with pulmonary arterial hypertension. This study aimed to examine the impact of NO plasma metabolites (NOx) relative to haemodynamic dysfunction and mortality in patients with idiopathic pulmonary arterial hypertension (IPAH).A total of 104 consecutive adult IPAH patients...
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