Article
Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma.
European journal of endocrinology - 1 Jan 2002
Blaker Michael, de Weerth Andreas, Tometten Mareike, Schulz Martina, Höppner Wolfgang, Arlt Dorit, Hoang-Vu Cuong, Dralle Henning, Terpe Harald, Jonas Ludwig, von Schrenck Tammo
Abstract excerpt
OBJECTIVE: The cholecystokinin(2)-receptor (CCK(2)R) promotes secretion and cell growth induced by its ligands cholecystokinin (CCK) and gastrin. The receptor has recently been shown to be expressed in human medullary thyroid carcinomas (MTCs). The objective of this study was to analyze CCK(2)R expression in MTC samples of different tumor stages as well as in non-malignant thyroid tissues. DESIGN AND METHODS:...
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