Article
Octreotide and pasireotide effects on medullary thyroid carcinoma (MTC) cells growth, migration and invasion.
Molecular and cellular endocrinology - 15 Jan 2021
Giardino E, Catalano R, Mangili F, Barbieri A M, Treppiedi D, Elli F M, Dolci A, Contarino A, Spada A, Arosio M, Mantovani G, Peverelli E
Abstract excerpt
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine neoplasm of the parafollicular thyroid C cells. Although somatostatin receptors are expressed by MTCs, treatment with octreotide has shown poor efficacy, whereas recently pasireotide has demonstrated antiproliferative effects in persistent postoperative MTCs. Aim of this study was to test the effects of octreotide and pasireotide on MTC cells...
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