Article
Prevalence and clinical spectrum of nonsecretory medullary thyroid carcinoma in a series of 839 patients with sporadic medullary thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association - 1 Mar 2013
Frank-Raue Karin, Machens Andreas, Leidig-Bruckner Gudrun, Rondot Susanne, Haag Christine, Schulze Egbert, Lorenz Angela, Kreissl Michael C, Dralle Henning, Raue Friedhelm, Schmid Kurt W
Abstract excerpt
BACKGROUND: Medullary thyroid carcinoma (MTC) is characterized by the synthesis and secretion of calcitonin (Ct). MTC without Ct secretion has been reported on rare occasions. The aim of this study was to analyze the prevalence and clinical spectrum of nonsecretory MTC in two tertiary centers that cared for 839 patients with sporadic MTC. METHODS: Clinical, biochemical, histological, and immunohistological...
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