Article
Clinical and pathological analysis of 19 cases of medullary thyroid carcinoma without an increase in calcitonin.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 2 Oct 2017
Zhou Qiufeng, Yue Shuanglei, Cheng Ye, Jin Ju, Xu Haimiao
Abstract excerpt
BACKGROUND: Medullary thyroid carcinoma (MTC), defined as a malignant tumour with C-cell differentiation, is of neuroendocrine origin and is characterized by the synthesis and secretion of calcitonin (CT). MTC without CT secretion has been reported on rare occasions. The purpose of this study was to evaluate the histological, immunohistochemical, and molecular pathologic features as well as the clinical...
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