Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of Cell Cycle for Enhancement of Antibody Productivity in Perfusion Culture of NS0 Cells

1 Jan 2003

Abstract excerpt

A prolonged period of high productivity at high cell density is desirable for industrial production of biopharmaceuticals. Previous efforts have shown that cessation of cell proliferation in low cell density culture results in increased productivity. We report here further results on multigenic manipulation of cell cycle and apoptosis to enhance productivity at high cell density. The NS0 6A1/4-9F myeloma cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12573029
DOI: 10.1021/bp025589f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of Cell Cycle for Enhancement of Antibody Productivity in Perfusion Culture of NS0 CellsPMID 12573029Read ↗

Detailed understanding of enhanced specific antibody productivity in NS0 myeloma cellsSemantic proximity Read ↗

Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell culturesSemantic proximity Read ↗

Specific monoclonal antibody productivity and the cell cycle-comparisons of batch, continuous and perfusion culturesSemantic proximity Read ↗

Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells.Semantic proximity Read ↗

Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditionsSemantic proximity Read ↗

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production processSemantic proximity Read ↗

Ectoine enhances recombinant antibody production in Chinese hamster ovary cells by promoting cell cycle arrestSemantic proximity Read ↗

Engineering death resistance in CHO cells for improved perfusion cultureSemantic proximity Read ↗

Combined gene and environmental engineering offers a synergetic strategy to enhance r‐protein production in Chinese hamster ovary cellsSemantic proximity Read ↗

Stable overexpression of mutated PTEN in Chinese hamster ovary cells enhances their performance and therapeutic antibody productionSemantic proximity Read ↗

Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO productionSemantic proximity Read ↗

Overexpression of cdk4/cyclin D1 induces apoptosis in PC12 cells in the presence of trophic support.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.