Article
The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.
Molecular and cellular biology - 1 Dec 2007
Kuroyanagi Hidehito, Ohno Genta, Mitani Shohei, Hagiwara Masatoshi
Abstract excerpt
Many pre-mRNAs are alternatively spliced in a tissue-specific manner in multicellular organisms. The Fox-1 family of RNA-binding proteins regulate alternative splicing by either activating or repressing exon inclusion through specific binding to UGCAUG stretches. However, the precise cellular contexts that determine the action of the Fox-1 family in vivo remain to be elucidated. We have recently demonstrated that...
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