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Article

Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix

1 Dec 1999

Abstract excerpt

Most cervical carcinomas appear to arise from cervical intraepithelial neoplasia (CIN) lesions. In addition to infection with high-risk human papilloma viruses, which is indicative of an increased risk of progression, alterations of oncogenes and tumor suppressor genes play a role. Genetic studies of CIN lesions, primary cervical carcinoma, and metastases may shed light on the relative importance of various...

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PMID: 10534770
DOI: 10.1002/(sici)1098-2264(199912)26:4<346::aid-gcc9>3.0.co;2-d

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