Article
Molecular profiling of cervical neoplasia.
Expert review of molecular diagnostics - 1 Mar 2006
Martin Cara M, Astbury Katharine, O'Leary John J
Abstract excerpt
Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Human papillomavirus is the single most important etiological agent in cervical cancer, contributing to neoplastic progression through the action of viral oncoproteins, mainly E6 and E7, which interfere with critical cell cycle pathways, p53 and retinoblastoma. However, evidence suggests that human...
Topics
- Biomarkers, Tumor
- DNA
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- MicroRNAs
- Molecular Diagnostic Techniques
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- RNA
- Uterine Cervical Neoplasms