Article
Failure of stavudine-lamivudine combination therapy in antiretroviral-naive patients with AZT-like HIV-1 resistance mutations.
Journal of medical virology - 1 Dec 2001
Sarmati L, Nicastri E, Parisi S G, D'Ettorre G, Narciso P, Mancino G, Gallo I, Abbadessa V, Dalle N E, Traina C, Vullo V, Andreoni M
Abstract excerpt
To analyze the clinical relevance of AZT resistance mutations in AZT-naive patients, 56 HIV-1 seropositive patients treated for 18 months with stavudine/lamivudine (27 patients) or AZT/lamivudine (29 patients) were studied. AZT-like resistance mutations were found in 13 out of 29 (44%) patients treated with AZT/lamivudine and in 11 out of 27 (40%) patients treated with stavudine/lamivudine. No stavudine or...
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