Article
Small changes in expression affect predisposition to tumorigenesis.
Nature genetics - 1 Jan 2002
Yan Hai, Dobbie Zuzana, Gruber Stephen B, Markowitz Sanford, Romans Kathy, Giardiello Francis M, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
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