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Article

Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions.

The EMBO journal - 17 Dec 2001

Glick E, Vigna K L, Loeb L A

Abstract excerpt

Human DNA polymerase eta (hPol eta) is one of the newly identified Y-family of DNA polymerases. These polymerases synthesize past template lesions that are postulated to block replication fork progression. hPol eta accurately bypasses UV-associated cis-syn cyclobutane thymine dimers in vitro and contributes to normal resistance to sunlight-induced skin cancer. We describe here mutational analysis of motif II, a...

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Share to Cloning, Molecular
Share to Dimerization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Mutagenesis, Site-Directed

Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 11743006
DOI: 10.1093/emboj/20.24.7303
PMCID: PMC125802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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