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Article

Structure-based prediction of modifications in glutarylamidase to allow single-step enzymatic production of 7-aminocephalosporanic acid from cephalosporin C.

Protein science : a publication of the Protein Society - 1 Jan 2002

Fritz-Wolf Karin, Koller Klaus-Peter, Lange Gudrun, Liesum Alexander, Sauber Klaus, Schreuder Herman, Aretz Werner, Kabsch Wolfgang

Abstract excerpt

Glutarylamidase is an important enzyme employed in the commercial production of 7-aminocephalosporanic acid, a starting compound in the synthesis of cephalosporin antibiotics. 7-aminocephalosporanic acid is obtained from cephalosporin C, a natural antibiotic, either chemically or by a two-step enzymatic process utilizing the enzymes D-amino acid oxidase and glutarylamidase. We have investigated possibilities for...

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Identifiers

PMID: 11742126
DOI: 10.1110/ps.27502
PMCID: PMC2368779

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Source receipt: pubmed, retrieved 7 Sept 2026.

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