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Article

Evolution of an acylase active on cephalosporin C.

Protein science : a publication of the Protein Society - 1 Dec 2005

Pollegioni Loredano, Lorenzi Simona, Rosini Elena, Marcone Giorgia Letizia, Molla Gianluca, Verga Roberto, Cabri Walter, Pilone Mirella S

Abstract excerpt

Semisynthetic cephalosporins are synthesized from 7-amino cephalosporanic acid, which is produced by chemical deacylation or by a two-step enzymatic process of the natural antibiotic cephalosporin C. The known acylases take glutaryl-7-amino cephalosporanic acid as a primary substrate, and their specificity and activity are too low for cephalosporin C. Starting from a known glutaryl-7-amino cephalosporanic acid...

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Identifiers

PMID: 16260759
DOI: 10.1110/ps.051671705
PMCID: PMC2253238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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