Article
Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.
PLoS genetics - 1 Nov 2020
Evans Kathryn S, Zdraljevic Stefan, Stevens Lewis, Collins Kimberly, Tanny Robyn E, Andersen Erik C
Abstract excerpt
Zinc is an essential trace element that acts as a co-factor for many enzymes and transcription factors required for cellular growth and development. Altering intracellular zinc levels can produce dramatic effects ranging from cell proliferation to cell death. To avoid such fates, cells have evolved mechanisms to handle both an excess and a deficiency of zinc. Zinc homeostasis is largely maintained via zinc...
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