Article
Lipid-facing correlated mutations and dimerization in G-protein coupled receptors.
Protein engineering - 1 Oct 2001
Gouldson P R, Dean M K, Snell C R, Bywater R P, Gkoutos G, Reynolds C A
Abstract excerpt
A correlated mutation analysis has been performed on the aligned protein sequences of a number of class A G-protein coupled receptor families, including the chemokine, neurokinin, opioid, somatostatin, thyrotrophin and the whole biogenic amine family. Many of the correlated mutations are observed flanking or neighbouring conserved residues. The correlated residues have been plotted onto the transmembrane portion...
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