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Article

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins.

Molecular biology of the cell - 1 Dec 2001

Bays N W, Wilhovsky S K, Goradia A, Hodgkiss-Harlow K, Hampton R Y

Abstract excerpt

We isolated a temperature-sensitive mutant, hrd4-1, deficient in ER-associated degradation (ERAD). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, our analysis revealed that HRD4/NPL4 is required for a poorly characterized step in ERAD after ubiquitination of target proteins but before their recognition by...

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Identifiers

PMID: 11739805
DOI: 10.1091/mbc.12.12.4114
PMCID: PMC60780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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