Article
The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.
Molecular biology of the cell - 1 Oct 2001
Hitchcock A L, Krebber H, Frietze S, Lin A, Latterich M, Silver P A
Abstract excerpt
Proteolytic activation of membrane-bound transcription factors has emerged as an important mechanism for the regulation of gene expression. Two membrane-bound transcription factors regulated in this manner are the Saccharomyces cerevisiae proteins Mga2p and Spt23p, which direct transcription of the Delta9-fatty acid desaturase gene OLE1. We now show that a membrane-associated complex containing the highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.