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Article

Dissection of nucleophilic and acid-base catalysis in glycosidases.

Current opinion in chemical biology - 1 Dec 2001

Zechel D L, Withers S G

Abstract excerpt

A startling array of added anions have been observed to function as replacement catalytic nucleophiles in mutant glycosidases, including formate, azide, fluoride and other halides. Likewise, the mechanism of acid-base catalysis is somewhat plastic. The carboxylic acids can be substituted by a sulfenic acid or by ascorbate, and the effective acid strength enhanced by the introduction of strong hydrogen bonds....

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Source

Identifiers

PMID: 11738173
DOI: 10.1016/s1367-5931(01)00260-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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