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Article

A functional assay for mutations in tumor suppressor genes caused by mismatch repair deficiency.

Human molecular genetics - 15 Nov 2001

Ji H P, King M C

Abstract excerpt

The coding sequences of multiple human tumor suppressor genes include microsatellite sequences that are prone to mutations. Saccharomyces cerevisiae strains deficient in DNA mismatch repair (MMR) can be used to determine de novo mutation rates of these human tumor suppressor genes as well as any other gene sequence. Microsatellites in human TGFBR2, PTEN and APC genes were placed in yeast vectors and analyzed in...

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Source

Identifiers

PMID: 11734538
DOI: 10.1093/hmg/10.24.2737

Genes

APC
PTEN
TGFBR2
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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