Article
Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 2001
Schiavello T, Burke V, Bogdanova N, Jasik P, Melsom S, Boudville N, Robertson K, Angelicheva D, Dworniczak B, Lemmens M, Horst J, Todorov V, Dimitrakov D, Sulowicz W, Krasniak A, Stompor T, Beilin L, Hallmayer J, Kalaydjieva L, Thomas M
Abstract excerpt
BACKGROUND: Previous studies concerning Alu I/D polymorphism in the ACE gene and ADPKD severity have used the Alu genotypes as a representative of the true biological variable, namely ACE activity. However, wide individual and ethnic differences in the proportion of variance in ACE activity explained by the I/D genotype may have confounded these studies. This investigation examines the association between ADPKD...
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