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Article

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

27 Apr 1999

Abstract excerpt

Human telomerase consists of two essential components, telomerase RNA template (hTER) and telomerase reverse transcriptase (hTERT), and functions to synthesize telomere repeats that serve to protect the integrity of chromosomes and to prolong the replicative life span of cells. Telomerase activity is expressed selectively in germ-line and malignant tumor cells but not in most normal human somatic cells. As a...

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PMID: 10220433
DOI: 10.1073/pnas.96.9.5147

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