Article
Expression of paraoxonase isoform did not confer protection from acute sarin poisoning in the Tokyo subway terrorist attack.
International journal of legal medicine - 1 Oct 2001
Yamada Y, Takatori T, Nagao M, Iwase H, Kuroda N, Yanagida J, Shinozuka T
Abstract excerpt
We previously reported the polymorphism of the high density lipoprotein-associated enzyme paraoxonase (PON1), in the 10 sarin poisoning victims in the Tokyo subway terrorist attack. Arg192 PON1, which has low sarin hydrolysing activity, was found to be more common in the Japanese population than in people of other races. However, from our analyses seven of the victims expressed the PON1 phenotype with high sarin...
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