Article
The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese.
Human genetics - 1 Nov 1997
Yamasaki Y, Sakamoto K, Watada H, Kajimoto Y, Hori M
Abstract excerpt
The high-density-lipoprotein-associated enzyme paraoxonase, which has a role in the detoxification of organophosphorus compounds, is known to be polymorphic in humans. The Arg192 isoform of paraoxonase hydrolyzes paraoxon more rapidly than the Gln192 isoform. However, with respect to the hydrolysis of toxic nerve agents, such as diazoxon, soman, and sarin, the Arg192 isoform displays a lower activity than the...
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