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Article

Thrombospondins, their polymorphisms, and cardiovascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2007

Stenina Olga I, Topol Eric J, Plow Edward F

Abstract excerpt

The thrombospondins are a 5-member gene family that mediate cell-cell and cell-matrix interactions. The thrombospondins are either trimers or pentamers, and their functions depend on their abilities to interact with numerous extracellular ligands and cell surface receptors through the multiple domains that compose each subunit. Recent genetic studies have indicated associations of particular single nucleotide...

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Identifiers

PMID: 17569883
DOI: 10.1161/ATVBAHA.107.141713

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