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Article

Hormone resistance caused by mutations in G proteins and G protein-coupled receptors.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Apr 1999

Spiegel A M

Abstract excerpt

G proteins couple receptors for many hormones to effectors that regulate second messenger metabolism. Several endocrine disorders have been shown to be caused by either loss or gain of function mutations in G proteins or G protein-coupled receptors. Pseudohypoparathyroidism (PHP), the first described example of a hormone resistance disorder, is characterized by renal resistance to parathyroid hormone (PTH)...

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Source

Identifiers

PMID: 10698594

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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