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Article

Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease.

Neuroscience letters - 2 Oct 2006

Temel Yasin, Cao Chunyan, Vlamings Rinske, Blokland Arjan, Ozen Hatice, Steinbusch Harry W M, Michelsen Kimmo A, von Hörsten Stephan, Schmitz Christoph, Visser-Vandewalle Veerle

Abstract excerpt

Altered activity of the globus pallidus externus (GPe) is responsible for at least part of the cognitive and motor symptoms of Huntington's disease (HD). In this study, we tested the hypothesis that bilateral globus pallidus (GP; equivalent of GPe in primates) deep brain stimulation (DBS) improves cognitive and motor symptoms in the first transgenic rat model of HD (tgHD rats). GP DBS with clinically relevant...

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Identifiers

PMID: 16905252
DOI: 10.1016/j.neulet.2006.07.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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