Article
Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
Neurobiology of disease - 1 Apr 2009
Ramaswamy Shilpa, McBride Jodi L, Han Ina, Berry-Kravis Elizabeth M, Zhou Lili, Herzog Christopher D, Gasmi Mehdi, Bartus Raymond T, Kordower Jeffrey H
Abstract excerpt
Members of the GDNF family of ligands, including neurturin (NTN), have been implicated as potential therapeutic agents for Huntington's disease (HD). The present study examined the ability of CERE-120 (AAV2-NTN) to provide structural and functional protection in the N171-82Q transgenic HD mouse model. AAV2-NTN therapy attenuated rotorod deficits in this mutant relative to control treated transgenics (p<0.01)....
Topics
- Animals
- Cerebral Cortex
- Corpus Striatum
- DNA-Binding Proteins
- Dependovirus
- Disease Models, Animal
- Gene Expression
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors