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Article

Design of allele-specific protein methyltransferase inhibitors.

Journal of the American Chemical Society - 28 Nov 2001

Lin Q, Jiang F, Schultz P G, Gray N S

Abstract excerpt

Protein arginine methyltransferases, which catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine side chains in target proteins, regulate transcription, RNA processing, and receptor-mediated signaling. To specifically address the functional role of the individual members of this family, we took a "bump-and-hole" approach and designed a series of N(6)-substituted S-adenosylhomocysteine...

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Identifiers

PMID: 11716715
DOI: 10.1021/ja011423j

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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