Article
The point mutation in the promoter region and the single nucleotide polymorphism in exon 1 of the cytokeratin 19 gene in human lung cancer cell lines.
Lung cancer (Amsterdam, Netherlands) - 1 Dec 2001
Fujita J, Dohmoto K, Hojo S, Ueda Y, Bandoh S, Yang Y, Yamaji Y, Ohtsuki Y, Ishida T
Abstract excerpt
The CYFRA 21-1 assay which detects the cytokeratin 19 (CK19) fragment is widely used as a tumor marker for lung cancer. We previously suggested that the failure of PCR amplification of exon 1 is closely related to the inability of the expression of mRNA for CK19, and hypothesized that point mutations might exist within exon 1. In order to prove this, sequence analysis of the promoter region and exon 1 was...
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