Article
Lack of acrosome formation in Hrb-deficient mice.
Science (New York, N.Y.) - 16 Nov 2001
Kang-Decker N, Mantchev G T, Juneja S C, McNiven M A, van Deursen J M
Abstract excerpt
The sperm acrosome is essential for sperm-egg fusion and is often defective in men with nonobstructive infertility. Here we report that male mice with a null mutation in Hrb are infertile and display round-headed spermatozoa that lack an acrosome. In wild-type spermatids, Hrb is associated with the cytosolic surface of proacrosomic transport vesicles that fuse to create a single large acrosomic vesicle at step 3...
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