Article
Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis.
The Journal of pathology - 1 Oct 2018
Kim Chongtae, Jeong Da Eun, Heo Sungeun, Ji Eunbyul, Rho Jun Gi, Jung Myeongwoo, Ahn Sojin, Kim Ye-Jin, Kim Yong-Sung, Nam Suk Woo, Kulkarni Rohit N, Lee Kyoung Bun, Lee Eun Kyung, Kim Wook
Abstract excerpt
For the majority of patients diagnosed with pancreatic neuroendocrine tumors (NETs), there is significant malignant potential with a poor prognosis; however, the molecular abnormalities and pathogenesis of pancreatic NETs have not been firmly established. Here, we report that loss of expression of the RNA-binding protein HuD correlates with low p27Kip1 (p27) levels and poor prognosis in pancreatic NETs. HuD...
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