Article
Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas.
British journal of cancer - 19 Oct 2001
Parry L, Maynard J H, Patel A, Clifford S C, Morrissey C, Maher E R, Cheadle J P, Sampson J R
Abstract excerpt
The genetic events involved in the aetiology of non-clear-cell renal cell carcinoma (RCC) and a proportion of clear cell RCC remain to be defined. Germline mutations of the TSC1 and TSC2 genes cause tuberous sclerosis (TSC), a multi-system hamartoma syndrome that is also associated with RCC. We assessed 17 sporadic clear cell RCCs with a previously identified VHL mutation, 15 clear-cell RCCs without an identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.