Article
P53 mutation and response to hepatic arterial floxuridine in patients with colorectal liver metastases.
Journal of cancer research and clinical oncology - 1 Nov 2001
Khan Z A, Jonas S K, Feldmann K A, Patel H, Wharton R Q, Tarragona A, Ivison A, Allen-Mersh T G
Abstract excerpt
PURPOSE: To establish the relationship between the number and site of p53 genomic mutations in metastatic colorectal cancer, and the response to hepatic arterial floxuridine. METHODS: Liver metastasis biopsies were collected, at the time of laparotomy for hepatic arterial cannulation. in 28 patients with metachronous colorectal liver metastases. p53 Gene mutations were assessed using reverse transcription, nested...
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