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Article

Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype.

Developmental biology - 1 Sept 1994

Copp A J, Checiu I, Henson J N

Abstract excerpt

Mouse embryos homozygous for the mutation loop-tail (Lp) develop lethal defects in which the neural tube remains open from the hindbrain to the caudal extremity, a condition that closely resembles the human malformation craniorachischisis. Heterozygotes develop tail defects and occasional spina bifida, but are generally viable. In order to study the early development of these defects, it is necessary to determine...

Topics

Animals
DNA, Satellite
Female
Genetic Linkage
Genetic Markers
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mutation
Neural Tube Defects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymorphism, Genetic

Source

Identifiers

PMID: 8088438
DOI: 10.1006/dbio.1994.1230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8088438-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype.PMID 8088438Read ↗

Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.Semantic proximity Read ↗

Identification of the mouse Loop-tail gene: a model for human craniorachischisis?Semantic proximity Read ↗

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.Semantic proximity Read ↗

Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.Semantic proximity Read ↗

Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).Semantic proximity Read ↗

Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping.Semantic proximity Read ↗

Genetic landmarks for defects in mouse neural tube closure.Semantic proximity Read ↗

All-or-none craniorachischisis in Loop-tail mutant mouse chimeras.Semantic proximity Read ↗

Loop-tail phenotype in heterozygous mice and neural tube defects in homozygous mice result from a nonsense mutation in the Vangl2 gene.Semantic proximity Read ↗

Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1.Semantic proximity Read ↗

Genetic basis of neural tube defects: the mouse gene loop-tail maps to a region of chromosome 1 syntenic with human 1q21-q23.Semantic proximity Read ↗

Cardiovascular Defects Associated With Abnormalities in Midline Development in the <i>Loop-tail</i> Mouse MutantSemantic proximity Read ↗

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