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Article

Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib.

Antimicrobial agents and chemotherapy - 1 Dec 2001

Shmara A, Weinsetel N, Dery K J, Chavideh R, Tolmasky M E

Abstract excerpt

Alanine-scanning mutagenesis was applied to the aminoglycoside 6'-N-acetyltransferase type Ib conserved motif B, and the effects of the substitutions were analyzed by measuring the MICs of kanamycin (KAN) and its semisynthetic derivative, amikacin (AMK). Several substitutions resulted in no major change in MICs. E167A and F171A resulted in derivatives that lost the ability to confer resistance to KAN and AMK....

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Identifiers

PMID: 11709299
DOI: 10.1128/AAC.45.12.3287-3292.2001
PMCID: PMC90828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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